| 名称 | ADCC Bioassay Effector Cell F variant （Low Affinit |
| 型号 | CBP74002 |
| 报价 |  |
| 特点 | ADCC Bioassay Effector Cell F variant （Low Affinity）- Fcγ-NFAT/Jurkat,母细胞：Jurkat，培养基：1640+10%FBS |
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> CBP74002ADCC Bioassay Effector Cell F variant （Low Affinit
- 详细内容
| I. Background | |
抗体依赖的细胞介导的细胞毒性作用（ADCC，antibody-dependent cell-mediated cytotoxicity ）是指抗体的 Fab 段结合病毒感染的细胞或肿瘤细胞的抗原表位，其 Fc 段与杀 伤细胞（NK 细胞、巨噬细胞等）表面的 FcR 结合，介导杀伤细胞直接杀伤靶细胞，它是 抗肿瘤的治疗性抗体药物发生作用的一种作用重要机制。 | |
| II. Description | |
ADCC Bioassay Effector Cell F variant (Low Affinity)-Fcγ-NFAT Jurkat 报告基因药靶模型 很好的模拟了体内 ADCC 的信号转导过程，原理见下图所示。
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| III. Introduction | |
| Host Cell: | Jurkat |
| Expressed gene: | NFAT-Luc-CD16(F158) |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | Antibody-dependent cell-mediated cytotoxicity |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+10%FBS |
| Mycoplasma Testing: | Negative |
| Storage: | Immediately upon receipt, store in liquid nitrogen. |
| Application(s): | Functional(Report Gene) Assay |
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | Peripheral blood |
| Disease: | Acute T cell leukemia |
| Morphology: | Lymphoblast |
| Growth Properties: | Suspension |
| Ⅴ. Representative Data | |
Figure 2. Recombinant ADCC Bioassay Effector Cell F variant (Low Affinity)- Fcγ-NFAT/Jurkat expressing CD16.
Figure 3. Dose response of CD20 Ab in ADCC Bioassay Effector Cell F variant (Low Affinity)-Fcγ-NFAT Jurkat (C11) with Raji.
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